5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) Effect on Glucose Production, but Not Energy Metabolism, Is Independent of Hepatic AMPK in Vivo

Metabolic stress, as well as several antidiabetic agents, increases hepatic nucleotide monophosphate (NMP) levels, activates AMP-activated protein kinase (AMPK), and suppresses glucose production. We tested the necessity of hepatic AMPK for the in vivo effects of an acute elevation in NMP on metabol...

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Hlavní autoři: Hasenour, Clinton M., Ridley, D. Emerson, Hughey, Curtis C., James, Freyja D., Donahue, E. Patrick, Shearer, Jane, Viollet, Benoit, Foretz, Marc, Wasserman, David H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937663/
https://ncbi.nlm.nih.gov/pubmed/24403081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.528232
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