5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) Effect on Glucose Production, but Not Energy Metabolism, Is Independent of Hepatic AMPK in Vivo

Metabolic stress, as well as several antidiabetic agents, increases hepatic nucleotide monophosphate (NMP) levels, activates AMP-activated protein kinase (AMPK), and suppresses glucose production. We tested the necessity of hepatic AMPK for the in vivo effects of an acute elevation in NMP on metabol...

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Detalhes bibliográficos
Main Authors: Hasenour, Clinton M., Ridley, D. Emerson, Hughey, Curtis C., James, Freyja D., Donahue, E. Patrick, Shearer, Jane, Viollet, Benoit, Foretz, Marc, Wasserman, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937663/
https://ncbi.nlm.nih.gov/pubmed/24403081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.528232
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