The ATP Sites of AAA+ Clamp Loaders Work Together as a Switch to Assemble Clamps on DNA

Clamp loaders belong to a family of proteins known as ATPases associated with various cellular activities (AAA+). These proteins utilize the energy from ATP binding and hydrolysis to perform cellular functions. The clamp loader is required to load the clamp onto DNA for use by DNA polymerases to inc...

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Bibliographic Details
Main Authors: Marzahn, Melissa R., Hayner, Jaclyn N., Finkelstein, Jeff, O'Donnell, Mike, Bloom, Linda B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937632/
https://ncbi.nlm.nih.gov/pubmed/24436332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.541466
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