AKT and GSK-3 Are Necessary for Direct Ezrin Binding to NHE3 as Part of a C-terminal Stimulatory Complex: ROLE OF A NOVEL SER-RICH NHE3 C-TERMINAL MOTIF IN NHE3 ACTIVITY AND TRAFFICKING

Basal activity of the BB Na(+)/H(+) exchanger NHE3 requires multiprotein complexes that form on its C terminus. One complex stimulates basal NHE3 activity and contains ezrin and phosphoinositides as major components; how it stimulates NHE3 activity is not known. This study tested the hypothesis that...

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Detalhes bibliográficos
Main Authors: Singh, Varsha, Lin, Rong, Yang, Jianbo, Cha, Boyoung, Sarker, Rafiquel, Tse, Chung Ming, Donowitz, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937621/
https://ncbi.nlm.nih.gov/pubmed/24398676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.521336
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