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CHES1/FOXN3 regulates cell proliferation by repressing PIM2 and protein biosynthesis

The expression of the forkhead transcription factor checkpoint suppressor 1 (CHES1), also known as FOXN3, is reduced in many types of cancers. We show here that CHES1 decreases protein synthesis and cell proliferation in tumor cell lines but not in normal fibroblasts. Conversely, short hairpin RNA–m...

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Autors principals: Huot, Geneviève, Vernier, Mathieu, Bourdeau, Véronique, Doucet, Laurent, Saint-Germain, Emmanuelle, Gaumont-Leclerc, Marie-France, Moro, Alejandro, Ferbeyre, Gerardo
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937083/
https://ncbi.nlm.nih.gov/pubmed/24403608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-02-0110
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