Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR

The multidrug efflux pump MepA is a major contributor to multidrug resistance in Staphylococcus aureus. MepR, a member of the multiple antibiotic resistance regulator (MarR) family, represses mepA and its own gene. Here, we report the structure of a MepR–mepR operator complex. Structural comparison...

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Bibliographic Details
Main Authors: Birukou, Ivan, Seo, Susan M., Schindler, Bryan D., Kaatz, Glenn W., Brennan, Richard G.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936728/
https://ncbi.nlm.nih.gov/pubmed/24293644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1215
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