The Molecular Mechanisms of Allosteric Mutations Impairing MepR Repressor Function in Multidrug-Resistant Strains of Staphylococcus aureus

Overexpression of the Staphylococcus aureus multidrug efflux pump MepA confers resistance to a wide variety of antimicrobials. mepA expression is controlled by MarR family member MepR, which represses mepA and autorepresses its own production. Mutations in mepR are a primary cause of mepA overexpres...

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Hlavní autoři: Birukou, Ivan, Tonthat, Nam K., Seo, Susan M., Schindler, Bryan D., Kaatz, Glenn W., Brennan, Richard G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Microbiology 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760248/
https://ncbi.nlm.nih.gov/pubmed/23982071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00528-13
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