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Mutations within the mepA Operator Affect Binding of the MepR Regulatory Protein and Its Induction by MepA Substrates in Staphylococcus aureus

The expression of mepA, encoding the Staphylococcus aureus MepA multidrug efflux protein, is repressed by the MarR homologue MepR. Repression occurs through binding of two MepR dimers to an operator with two homologous and closely approximated pseudopalindromic binding sites (site 1 [S1] and site 2...

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發表在:J Bacteriol
Main Authors: Schindler, Bryan D., Seo, Susan M., Birukou, Ivan, Brennan, Richard G., Kaatz, Glenn W.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336350/
https://ncbi.nlm.nih.gov/pubmed/25583977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.02558-14
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