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Mutations within the mepA Operator Affect Binding of the MepR Regulatory Protein and Its Induction by MepA Substrates in Staphylococcus aureus

The expression of mepA, encoding the Staphylococcus aureus MepA multidrug efflux protein, is repressed by the MarR homologue MepR. Repression occurs through binding of two MepR dimers to an operator with two homologous and closely approximated pseudopalindromic binding sites (site 1 [S1] and site 2...

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Detalhes bibliográficos
Publicado no:J Bacteriol
Main Authors: Schindler, Bryan D., Seo, Susan M., Birukou, Ivan, Brennan, Richard G., Kaatz, Glenn W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336350/
https://ncbi.nlm.nih.gov/pubmed/25583977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.02558-14
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