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β-Secretase Cleavage of the Fly Amyloid Precursor Protein Is Required for Glial Survival
β-secretase (or BACE1) is the key enzyme in the production of β-amyloid (Aβ), which accumulates in the senile plaques characteristic for Alzheimer's disease. Consequently, the lack of BACE1 prevents β-processing of the amyloid precursor protein and Aβ production, which made it a promising targe...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Society for Neuroscience
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3936607/ https://ncbi.nlm.nih.gov/pubmed/23152602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0228-12.2012 |
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