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β-Secretase Cleavage of the Fly Amyloid Precursor Protein Is Required for Glial Survival

β-secretase (or BACE1) is the key enzyme in the production of β-amyloid (Aβ), which accumulates in the senile plaques characteristic for Alzheimer's disease. Consequently, the lack of BACE1 prevents β-processing of the amyloid precursor protein and Aβ production, which made it a promising targe...

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Autors principals: Bolkan, Bonnie J., Triphan, Tilman, Kretzschmar, Doris
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936607/
https://ncbi.nlm.nih.gov/pubmed/23152602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0228-12.2012
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