Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study

BACKGROUND: ALK fusion genes occur in a subset of non-small-cell lung cancers (NSCLCs). We assessed the tolerability and activity of crizotinib in patients with NSCLC who were prospectively identified to have an ALK fusion within the first-in-man phase 1 crizotinib study. METHODS: In this phase 1 st...

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Hoofdauteurs: Camidge, D Ross, Bang, Yung-Jue, Kwak, Eunice L, Iafrate, A John, Varella-Garcia, Marileila, Fox, Stephen B, Riely, Gregory J, Solomon, Benjamin, Ou, Sai-Hong I, Kim, Dong-Wan, Salgia, Ravi, Fidias, Panagiotis, Engelman, Jeffrey A, Gandhi, Leena, Jänne, Pasi A, Costa, Daniel B, Shapiro, Geoffrey I, LoRusso, Patricia, Ruffner, Katherine, Stephenson, Patricia, Tang, Yiyun, Wilner, Keith, Clark, Jeffrey W, Shaw, Alice T
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936578/
https://ncbi.nlm.nih.gov/pubmed/22954507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(12)70344-3
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