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Crizotinib in ROS1-Rearranged Non–Small-Cell Lung Cancer
BACKGROUND: Chromosomal rearrangements of the gene encoding ROS1 proto-oncogene receptor tyrosine kinase (ROS1) define a distinct molecular subgroup of non–small-cell lung cancers (NSCLCs) that may be susceptible to therapeutic ROS1 kinase inhibition. Crizotinib is a small-molecule tyrosine kinase i...
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| Publicado en: | N Engl J Med |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4264527/ https://ncbi.nlm.nih.gov/pubmed/25264305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1406766 |
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