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Crizotinib in ROS1-Rearranged Non–Small-Cell Lung Cancer

BACKGROUND: Chromosomal rearrangements of the gene encoding ROS1 proto-oncogene receptor tyrosine kinase (ROS1) define a distinct molecular subgroup of non–small-cell lung cancers (NSCLCs) that may be susceptible to therapeutic ROS1 kinase inhibition. Crizotinib is a small-molecule tyrosine kinase i...

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Publicado en:N Engl J Med
Autores principales: Shaw, Alice T., Ou, Sai-Hong I., Bang, Yung-Jue, Camidge, D. Ross, Solomon, Benjamin J., Salgia, Ravi, Riely, Gregory J., Varella-Garcia, Marileila, Shapiro, Geoffrey I., Costa, Daniel B., Doebele, Robert C., Le, Long Phi, Zheng, Zongli, Tan, Weiwei, Stephenson, Patricia, Shreeve, S. Martin, Tye, Lesley M., Christensen, James G., Wilner, Keith D., Clark, Jeffrey W., Iafrate, A. John
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4264527/
https://ncbi.nlm.nih.gov/pubmed/25264305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1406766
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