Hypoxia-Inducible Factor-1α Causes Renal Cyst Expansion through Calcium-Activated Chloride Secretion

Polycystic kidney diseases are characterized by numerous bilateral renal cysts that continuously enlarge and, through compression of intact nephrons, lead to a decline in kidney function over time. We previously showed that cyst enlargement is accompanied by regional hypoxia, which results in the st...

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Bibliografiske detaljer
Main Authors: Buchholz, Bjoern, Schley, Gunnar, Faria, Diana, Kroening, Sven, Willam, Carsten, Schreiber, Rainer, Klanke, Bernd, Burzlaff, Nicolai, Jantsch, Jonathan, Kunzelmann, Karl, Eckardt, Kai-Uwe
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2014
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935579/
https://ncbi.nlm.nih.gov/pubmed/24203996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013030209
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