The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis

Background. Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of renal failure. Aberrant epithelial cell proliferation is a major cause of progressive cyst enlargement in ADPKD. Since activation of the Ras/Raf signaling system has been detected in cyst-lining epithelia, inhibiti...

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Detalhes bibliográficos
Publicado no:Nephrol Dial Transplant
Main Authors: Buchholz, Bjoern, Klanke, Bernd, Schley, Gunnar, Bollag, Gideon, Tsai, James, Kroening, Sven, Yoshihara, Daisuke, Wallace, Darren P., Kraenzlin, Bettina, Gretz, Norbert, Hirth, Peter, Eckardt, Kai-Uwe, Bernhardt, Wanja M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
II. Scientific Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281052/
https://ncbi.nlm.nih.gov/pubmed/21804086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gfr432
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