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Dysfunction of outer segment guanylate cyclase caused by retinal disease related mutations

Membrane bound guanylate cyclases are expressed in rod and cone cells of the vertebrate retina and mutations in several domains of rod outer segment guanylate cyclase 1 (ROS-GC1 encoded by the gene GUCY2D) correlate with different forms of retinal degenerations. In the present work we investigated t...

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Autors principals: Zägel, Patrick, Koch, Karl-Wilhelm
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935488/
https://ncbi.nlm.nih.gov/pubmed/24616660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2014.00004
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