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Dysfunction of outer segment guanylate cyclase caused by retinal disease related mutations

Membrane bound guanylate cyclases are expressed in rod and cone cells of the vertebrate retina and mutations in several domains of rod outer segment guanylate cyclase 1 (ROS-GC1 encoded by the gene GUCY2D) correlate with different forms of retinal degenerations. In the present work we investigated t...

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Detalhes bibliográficos
Main Authors: Zägel, Patrick, Koch, Karl-Wilhelm
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935488/
https://ncbi.nlm.nih.gov/pubmed/24616660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2014.00004
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