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Effect of CYP2B6*6 and CYP2C19*2 genotype on chlorpyrifos metabolism
Chlorpyrifos (CPF) is a widely used organophosphorus (OP) pesticide. CPF is bioactivated by cytochrome P450s (CYPs) to the potent cholinesterase inhibitor chlorpyrifos oxon (CPF-O) or detoxified to 3,5,6-trichloro-2-pyridinol (TCPy). Human CYP2B6 has the highest reported V(max)/K(m) (intrinsic clear...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3935332/ https://ncbi.nlm.nih.gov/pubmed/22281205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2012.01.006 |
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