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Bioactivation of chlorpyrifos by CYP2B6 variants
1. Chlorpyrifos (CPF), an organophosphorus (OP) pesticide, is bioactivated by cytochrome P450s (CYPs) to the active metabolite chlorpyrifos oxon (CPF-O). Given that human CYP2B6 has the highest intrinsic clearance (CL(int)) for CPF bioactivation, CYP2B6 polymorphisms may impact human susceptibility...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3520513/ https://ncbi.nlm.nih.gov/pubmed/22775490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/00498254.2012.702246 |
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