The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver

AIMS: To investigate in a large panel of 50 human liver samples the contribution of CYP2C9, CYP2D6, and CYP3A4 to the overall formation of the potent antioestrogen Z-4-hydroxy-tamoxifen, and how various genotypes affect its formation from tamoxifen. METHODS: The formation of Z-4-hydroxy-tamoxifen fr...

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Detalhes bibliográficos
Main Authors: Coller, Janet K, Krebsfaenger, Niels, Klein, Kathrin, Endrizzi, Karin, Wolbold, Renzo, Lang, Thomas, Nüssler, Andreas, Neuhaus, Peter, Zanger, Ulrich M, Eichelbaum, Michel, Mürdter, Thomas E
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Drug Disposition
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874408/
https://ncbi.nlm.nih.gov/pubmed/12207635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01614.x
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