Isoniazid Mediates the CYP2B6*6 Genotype-Dependent Interaction between Efavirenz and Antituberculosis Drug Therapy through Mechanism-Based Inactivation of CYP2A6

Efavirenz is commonly used to treat patients coinfected with human immunodeficiency virus and tuberculosis. Previous clinical studies have observed paradoxically elevated efavirenz plasma concentrations in patients with the CYP2B6*6/*6 genotype (but not the CYP2B6*1/*1 genotype) during coadministrat...

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Detalhes bibliográficos
Main Authors: Court, Michael H., Almutairi, Fawziah E., Greenblatt, David J., Hazarika, Suwagmani, Sheng, Hongyan, Klein, Kathrin, Zanger, Ulrich M., Bourgea, Joanne, Patten, Christopher J., Kwara, Awewura
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068589/
https://ncbi.nlm.nih.gov/pubmed/24820076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02532-14
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