Isoniazid Mediates the CYP2B6*6 Genotype-Dependent Interaction between Efavirenz and Antituberculosis Drug Therapy through Mechanism-Based Inactivation of CYP2A6

Efavirenz is commonly used to treat patients coinfected with human immunodeficiency virus and tuberculosis. Previous clinical studies have observed paradoxically elevated efavirenz plasma concentrations in patients with the CYP2B6*6/*6 genotype (but not the CYP2B6*1/*1 genotype) during coadministrat...

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Hlavní autoři: Court, Michael H., Almutairi, Fawziah E., Greenblatt, David J., Hazarika, Suwagmani, Sheng, Hongyan, Klein, Kathrin, Zanger, Ulrich M., Bourgea, Joanne, Patten, Christopher J., Kwara, Awewura
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068589/
https://ncbi.nlm.nih.gov/pubmed/24820076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02532-14
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