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HDACs link the DNA damage response, processing of double-strand breaks and autophagy
Protein acetylation is mediated by histone acetyltransferases (HATs) and deacetylases (HDACs), which influence chromatin dynamics, protein turnover and the DNA damage response. ATM and ATR mediate DNA damage checkpoints by sensing double-strand breaks and single-strand-DNA–RFA nucleofilaments, respe...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3935290/ https://ncbi.nlm.nih.gov/pubmed/21368826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09803 |
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