Regulation of β(2)-Adrenergic Receptor Function by Conformationally Selective Single-Domain Intrabodies

The biologic activity induced by ligand binding to orthosteric or allosteric sites on a G protein–coupled receptor (GPCR) is mediated by stabilization of specific receptor conformations. In the case of the β(2) adrenergic receptor, these ligands are generally small-molecule agonists or antagonists....

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Detalhes bibliográficos
Main Authors: Staus, Dean P., Wingler, Laura M., Strachan, Ryan T., Rasmussen, Soren G. F., Pardon, Els, Ahn, Seungkirl, Steyaert, Jan, Kobilka, Brian K., Lefkowitz, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935154/
https://ncbi.nlm.nih.gov/pubmed/24319111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.089516
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