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Regulation of β(2)-Adrenergic Receptor Function by Conformationally Selective Single-Domain Intrabodies
The biologic activity induced by ligand binding to orthosteric or allosteric sites on a G protein–coupled receptor (GPCR) is mediated by stabilization of specific receptor conformations. In the case of the β(2) adrenergic receptor, these ligands are generally small-molecule agonists or antagonists....
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| Hoofdauteurs: | , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3935154/ https://ncbi.nlm.nih.gov/pubmed/24319111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.089516 |
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