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Sphingolipid Signaling Reduces Basal P-Glycoprotein Activity in Renal Proximal Tubule
P-glycoprotein is an ATP-driven xenobiotic export pump that is highly expressed in barrier and excretory tissues, where it greatly influences drug pharmacokinetics. Recent studies in the blood-brain and spinal cord barriers identified a sphingolipid-based signaling pathway that regulates basal activ...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3935147/ https://ncbi.nlm.nih.gov/pubmed/24385389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.210641 |
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