Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain

P-glycoprotein, an ATP-driven drug efflux pump, is a major obstacle to the delivery of small-molecule drugs across the blood-brain barrier and into the CNS. Here we test a unique signaling-based strategy to overcome this obstacle. We used a confocal microscopy-based assay with isolated rat brain cap...

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Hlavní autoři: Cannon, Ronald E., Peart, John C., Hawkins, Brian T., Campos, Christopher R., Miller, David S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465435/
https://ncbi.nlm.nih.gov/pubmed/22949658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203534109
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