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Activation of PKC isoform β(I) at the blood–brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain
P-glycoprotein is an ATP (adenosine triphosphate)-driven drug efflux transporter that is highly expressed at the blood–brain barrier (BBB) and is a major obstacle to the pharmacotherapy of central nervous system diseases, including brain tumors, neuro-AIDS, and epilepsy. Previous studies have shown...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2949219/ https://ncbi.nlm.nih.gov/pubmed/20197783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.21 |
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