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Mrp1 is essential for sphingolipid signaling to p-glycoprotein in mouse blood–brain and blood–spinal cord barriers
At the blood–brain and blood–spinal cord barriers, P-glycoprotein, an ATP-driven drug efflux pump, is a major obstacle to central nervous system (CNS) pharmacotherapy. Recently, we showed that signaling through tumor necrosis factor-α (TNF-α), sphingolipids, and sphingosine-1-phosphate receptor 1 (S...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3587808/ https://ncbi.nlm.nih.gov/pubmed/23168528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.174 |
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