Nrf2 Upregulates ATP Binding Cassette Transporter Expression and Activity at the Blood–Brain and Blood–Spinal Cord Barriers

Activation of nuclear factor E2-related factor-2 (Nrf2), a sensor of oxidative stress, is neuroprotective in animal models of cerebral ischemia, traumatic brain injury, subarachnoid hemorrhage, and spinal cord injury. We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro incr...

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Hlavní autoři: Wang, Xueqian, Campos, Christopher R., Peart, John C., Smith, Lindsay K., Boni, Jessica L., Cannon, Ronald E., Miller, David S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4061395/
https://ncbi.nlm.nih.gov/pubmed/24948812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2935-13.2014
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