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Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier

Many widespread and persistent organic pollutants, e.g., 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), activate the aryl hydrocarbon receptor (AhR), causing it to translocate to the cell nucleus, where it transactivates target genes. AhR's ability to target the blood-brain barrier is essentially...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wang, Xueqian, Hawkins, Brian T., Miller, David S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Federation of American Societies for Experimental Biology 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023393/
https://ncbi.nlm.nih.gov/pubmed/21048045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-169227
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