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Constitutive Androstane Receptor-Mediated Up-Regulation of ATP-Driven Xenobiotic Efflux Transporters at the Blood-Brain Barrier

ATP-driven efflux transporters at the blood-brain barrier both protect against neurotoxicants and limit drug delivery to the brain. In other barrier and excretory tissues, efflux transporter expression is regulated by certain ligand-activated nuclear receptors. Here we identified constitutive andros...

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Detalhes bibliográficos
Main Authors: Wang, Xueqian, Sykes, Destiny B., Miller, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939489/
https://ncbi.nlm.nih.gov/pubmed/20547735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.063685
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