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Mrp1 is essential for sphingolipid signaling to p-glycoprotein in mouse blood–brain and blood–spinal cord barriers

At the blood–brain and blood–spinal cord barriers, P-glycoprotein, an ATP-driven drug efflux pump, is a major obstacle to central nervous system (CNS) pharmacotherapy. Recently, we showed that signaling through tumor necrosis factor-α (TNF-α), sphingolipids, and sphingosine-1-phosphate receptor 1 (S...

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Autors principals: Cartwright, Tara A, Campos, Christopher R, Cannon, Ronald E, Miller, David S
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587808/
https://ncbi.nlm.nih.gov/pubmed/23168528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.174
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