Regulation of P-Glycoprotein in Renal Proximal Tubule Epithelial Cells by LPS and TNF-α

During endotoxemia, the ATP-dependent drug efflux pump P-glycoprotein (Abcb1/P-gp) is upregulated in kidney proximal tubule epithelial cells. The signaling pathway through which lipopolysaccharide (LPS) or tumor necrosis factor-α (TNF-α) regulates P-gp expression and activity was investigated furthe...

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Autori principali: Heemskerk, Suzanne, Peters, Janny G. P., Louisse, Jochem, Sagar, Seil, Russel, Frans G. M., Masereeuw, Rosalinde
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841251/
https://ncbi.nlm.nih.gov/pubmed/20300455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/525180
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