Rapid, Nongenomic Stimulation of Multidrug Resistance Protein 2 (Mrp2) Activity by Glucocorticoids in Renal Proximal Tubule

In renal proximal tubule, multidrug resistance protein 2 (Mrp2) actively transports many organic anions into urine, including drugs and metabolic wastes. Upon exposure to nephrotoxicants or during endotoxemia, both Mrp2 activity and expression are up-regulated. This may result from induced de novo s...

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Detalhes bibliográficos
Main Authors: Prevoo, Brigitte, Miller, David S., van de Water, Femke M., Wever, Kimberley E., Russel, Frans G. M., Flik, Gert, Masereeuw, Rosalinde
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126637/
https://ncbi.nlm.nih.gov/pubmed/21515814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.179689
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