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Characterization of T-5 N-Oxide Formation as the First Highly Selective Measure of CYP3A5 Activity
Almost half of prescription medications are metabolized by cytochrome P450 3A4 and 3A5. CYP3A4 and 3A5 have significant substrate overlap, and there is currently no way to selectively monitor the activity of these two enzymes, which has led to the erroneous habit of attributing the cumulative activi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3935135/ https://ncbi.nlm.nih.gov/pubmed/24335391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.054726 |
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