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Synthesis and SAR of Lehualide B – A Marine-derived Natural Product with Potent Anti-Multiple Myeloma Activity
We report a concise and convergent laboratory synthesis of the rare marine natural product lehualide B that has led to the discovery that: (1) this compound has low nanomolar activity against human multiple myeloma cells, and (2) the anti-cancer effects of lehualide B and its analogs are selective (...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3758376/ https://ncbi.nlm.nih.gov/pubmed/23547759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300582s |
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