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Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid

X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder caused by impaired degradation of very long-chain fatty acids (VLCFAs) due to mutations in the ABCD1 gene responsible for VLCFA transport into peroxisomes. Lorenzo's oil, a 4:1 mixture of glyceryl trioleate and glyceryl trierucate,...

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Autori principali: Sassa, Takayuki, Wakashima, Takeshi, Ohno, Yusuke, Kihara, Akio
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934736/
https://ncbi.nlm.nih.gov/pubmed/24489110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M044586
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