Cooperative Synthesis of Ultra Long-Chain Fatty Acid and Ceramide during Keratinocyte Differentiation

The lipid lamellae in the stratum corneum is important for the epidermal permeability barrier. The lipid lamellae component ceramide (CER), comprising an ultra long-chain (ULC) fatty acid (FA) of ≥26 carbons (ULC CER), plays an essential role in barrier formation. ULC acyl-CoAs, produced by the FA e...

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Bibliographic Details
Main Authors: Mizutani, Yukiko, Sun, Hui, Ohno, Yusuke, Sassa, Takayuki, Wakashima, Takeshi, Obara, Mari, Yuyama, Kohei, Kihara, Akio, Igarashi, Yasuyuki
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694974/
https://ncbi.nlm.nih.gov/pubmed/23826266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067317
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