Substrate Envelope Designed Potent HIV-1 Protease Inhibitors to Avoid Drug Resistance

The rapid evolution of HIV under selective drug pressure has led to multi-drug resistant (MDR) strains that evade standard therapies. We designed highly potent HIV-1 protease inhibitors (PIs) using the substrate envelope model, which confines inhibitors within the consensus volume of natural substra...

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Detalles Bibliográficos
Autores principales: Nalam, Madhavi N.L., Ali, Akbar, Reddy, G.S. Kiran Kumar, Cao, Hong, Anjum, Saima G., Altman, Michael D., Yilmaz, Nese Kurt, Tidor, Bruce, Rana, Tariq M., Schiffer, Celia A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934494/
https://ncbi.nlm.nih.gov/pubmed/24012370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.07.014
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