A statin-dependent QTL for GATM expression is associated with statin-induced myopathy

Statins are widely prescribed for lowering plasma low-density lipoprotein (LDL) concentrations and cardiovascular disease risk(1), but there is considerable interindividual variation in treatment response(2,3) and increasing concern regarding the potential for adverse effects, including myopathy(4)...

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Main Authors: Mangravite, Lara M., Engelhardt, Barbara E., Medina, Marisa W., Smith, Joshua D., Brown, Christopher D., Chasman, Daniel I., Mecham, Brigham H., Howie, Bryan, Shim, Heejung, Naidoo, Devesh, Feng, QiPing, Rieder, Mark J., Chen, Y-D I., Rotter, Jerome I., Ridker, Paul M., Hopewell, Jemma C., Parish, Sarah, Armitage, Jane, Collins, Rory, Wilke, Russell A., Nickerson, Deborah A., Stephens, Matthew, Krauss, Ronald M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933266/
https://ncbi.nlm.nih.gov/pubmed/23995691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12508
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