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Hrq1, a homolog of the human RecQ4 helicase, acts catalytically and structurally to promote genome integrity
Human RecQ4 affects cancer and aging, but it is difficult to study because it is a fusion between a helicase and an essential replication factor. Budding yeast Hrq1 is homologous to the disease-linked helicase domain of RecQ4 and, like hRecQ4, was a robust 3’–5’ helicase. Additionally, Hrq1 had the...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3933191/ https://ncbi.nlm.nih.gov/pubmed/24440721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.12.037 |
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