Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α

One of the major metabolic changes associated with cellular transformation is enhanced nutrient utilization, which supports tumor progression by fueling both energy production and providing biosynthetic intermediates for growth. The liver kinase B1 (LKB1) is a serine/threonine kinase and tumor suppr...

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Detalhes bibliográficos
Main Authors: Faubert, Brandon, Vincent, Emma E., Griss, Takla, Samborska, Bozena, Izreig, Said, Svensson, Robert U., Mamer, Orval A., Avizonis, Daina, Shackelford, David B., Shaw, Reuben J., Jones, Russell G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932920/
https://ncbi.nlm.nih.gov/pubmed/24550282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312570111
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