Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination

NRF2 is a transcription factor that mediates stress responses. Oncogenic mutations in NRF2 localize to one of its two binding interfaces with KEAP1, an E3 ubiquitin ligase that promotes proteasome-dependent degradation of NRF2. Somatic mutations in KEAP1 occur commonly in human cancer, where KEAP1 m...

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Autori principali: Hast, Bridgid E., Cloer, Erica W., Goldfarb, Dennis, Li, Heng, Siesser, Priscila F., Yan, Feng, Walter, Vonn, Zheng, Ning, Hayes, D. Neil, Major, Michael B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932503/
https://ncbi.nlm.nih.gov/pubmed/24322982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1655
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