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Bmi1 is required for tumorigenesis in a mouse model of intestinal cancer

The epigenetic regulator BMI1 is upregulated progressively in a wide variety of human tumors including colorectal cancer. In this study, we assessed the requirement for Bmi1 in intestinal tumorigenesis using an autochthonous mouse model in which Apc was conditionally ablated in the intestinal epithe...

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Autori principali: Maynard, Mindy A., Ferretti, Roberta, Hilgendorf, Keren I., Perret, Christine, Whyte, Peter, Lees, Jacqueline A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931743/
https://ncbi.nlm.nih.gov/pubmed/23955081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.333
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