The Dichotomous Pattern of IL-12R and IL-23R Expression Elucidates the Role of IL-12 and IL-23 in Inflammation

IL-12 and IL-23 cytokines respectively drive Th1 and Th17 type responses. Yet, little is known regarding the biology of these receptors. As the IL-12 and IL-23 receptors share a common subunit, it has been assumed that these receptors are co-expressed. Surprisingly, we find that the expression of ea...

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Auteurs principaux: Chognard, Gaëlle, Bellemare, Lisa, Pelletier, Adam-Nicolas, Dominguez-Punaro, Maria C., Beauchamp, Claudine, Guyon, Marie-Josée, Charron, Guy, Morin, Nicolas, Sivanesan, Durga, Kuchroo, Vijay, Xavier, Ramnik, Michnick, Stephen W., Chemtob, Sylvain, Rioux, John D., Lesage, Sylvie
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931659/
https://ncbi.nlm.nih.gov/pubmed/24586521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089092
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