IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking

Genome-wide association studies as well as murine models have shown that the interleukin 23 receptor (IL23R) pathway plays a pivotal role in chronic inflammatory diseases such as Crohn disease (CD), ulcerative colitis, psoriasis, and type 1 diabetes. Genome-wide association studies and targeted re-s...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Sivanesan, Durga, Beauchamp, Claudine, Quinou, Christiane, Lee, Jonathan, Lesage, Sylvie, Chemtob, Sylvain, Rioux, John D., Michnick, Stephen W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861437/
https://ncbi.nlm.nih.gov/pubmed/26887945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.715870
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