A novel class of anti-IL-12p40 antibodies: Potent neutralization via inhibition of IL-12-IL-12Rβ2 and IL-23-IL-23R

While current therapeutic antibodies bind to IL-12 and IL-23 and inhibit their binding to IL-12Rβ1, we describe a novel antibody, termed 6F6, that binds to IL-12 and IL-23 and inhibits the interaction of IL-12 and IL-23 with their cognate signaling receptors IL-12Rβ2 and IL23R. This antibody does no...

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Main Authors: Clarke, Adam W, Poulton, Lynn, Wai, Hoi Yi, Walker, Stuart A, Victor, Shanti David, Domagala, Teresa, Mraovic, Dragana, Butt, Danyal, Shewmaker, Nina, Jennings, Philip, Doyle, Anthony G
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958575/
https://ncbi.nlm.nih.gov/pubmed/20724822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.2.5.13081
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