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Sirtuin 3 Deficiency Does Not Augment Hypoxia-Induced Pulmonary Hypertension
Alveolar hypoxia elicits increases in mitochondrial reactive oxygen species (ROS) signaling in pulmonary arterial (PA) smooth muscle cells (PASMCs), triggering hypoxic pulmonary vasoconstriction. Mice deficient in sirtuin (Sirt) 3, a nicotinamide adenine dinucleotide–dependent mitochondrial deacetyl...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Thoracic Society
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3931121/ https://ncbi.nlm.nih.gov/pubmed/24047466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0191OC |
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