Regulation of Hypoxia-induced Pulmonary Hypertension by Vascular Smooth Muscle Hypoxia-Inducible Factor-1α

Rationale: Chronic hypoxia induces pulmonary vascular remodeling, pulmonary hypertension, and right ventricular hypertrophy. At present, little is known about mechanisms driving these responses. Hypoxia-inducible factor-1α (HIF-1α) is a master regulator of transcription in hypoxic cells, up-regulati...

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Detalhes bibliográficos
Main Authors: Ball, Molly K., Waypa, Gregory B., Mungai, Paul T., Nielsen, Jacqueline M., Czech, Lyubov, Dudley, V. Joseph, Beussink, Lauren, Dettman, Robert W., Berkelhamer, Sara K., Steinhorn, Robin H., Shah, Sanjiv J., Schumacker, Paul T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977726/
https://ncbi.nlm.nih.gov/pubmed/24251580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201302-0302OC
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