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Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels

AMP-activated protein kinase (AMPK) is an energy sensor activated by increases in [AMP] or by oxidant stress (reactive oxygen species [ROS]). Hypoxia increases cellular ROS signaling, but the pathways underlying subsequent AMPK activation are not known. We tested the hypothesis that hypoxia activate...

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Detalhes bibliográficos
Main Authors: Mungai, Paul T., Waypa, Gregory B., Jairaman, Amit, Prakriya, Murali, Dokic, Danijela, Ball, Molly K., Schumacker, Paul T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165558/
https://ncbi.nlm.nih.gov/pubmed/21670147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05124-11
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